Queen Shanakdakhete took the Throne of Kush Empire in ancient Nubia from 170 to 150 BC. The Queen ruled with absolute power in the Meroë Empire as well. As a result, the Queen became known as the Lord of the Two Lands. The Queen also exercised power without the support of a king, which was unusual for the time.
Source: The untold story of the great Nubian Queen Shanakdakhete who ruled without a king | The African History